How Generalizable are Randomized Controlled trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies

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dc.contributor.authorBai, Anthony
dc.contributor.authorLo, Carson K. L.
dc.contributor.authorKomorowski, Adam
dc.contributor.authorSuresh, Mallika
dc.contributor.authorGuo, Kevin
dc.contributor.authorGarg, Akhil
dc.contributor.authorTandon, Pranav
dc.contributor.authorSenecal, Julien
dc.contributor.authorDel Corpo, Olivier
dc.contributor.authorStefanova, Isabella
dc.contributor.authorFogarty, Clare
dc.contributor.authorButler-Laporte, Guillaume
dc.contributor.authorMcDonald, Emily
dc.contributor.authorCheng, Matthew P.
dc.contributor.authorMorris, Andrew M.
dc.contributor.authorLoeb, Mark
dc.contributor.authorLee, Todd
dc.date.accessioned2022-04-28T18:59:53Z
dc.date.available2022-04-28T18:59:53Z
dc.date.issued2022-03-04
dc.descriptionThis is an Accepted Manuscript of an article published by Oxford University Press in the journal Clinical Infectious Diseases on March 4, 2022 available online at https://doi.org/10.1093/cid/ciac177en
dc.description.abstractIn Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.en
dc.identifier.citationAnthony D Bai, MD, Carson K L Lo, MD, Adam S Komorowski, MD, Mallika Suresh, HBSc, Kevin Guo, Akhil Garg, MDCM, Pranav Tandon, MSc, Julien Senecal, BSc, Olivier Del Corpo, MDCM MSc, Isabella Stefanova, BSc, Clare Fogarty, MDCM, Guillaume Butler-Laporte, MD, Emily G McDonald, MD MSc, Matthew P Cheng, MDCM, Andrew M Morris, MD SM, Mark Loeb, MD MSc, Todd C Lee, MD MPH, How generalizable are randomized controlled trials (RCTs) in Staphylococcus aureus bacteremia? A description of the mortality gap between RCTs and observational studies, Clinical Infectious Diseases, 2022;, ciac177, https://doi.org/10.1093/cid/ciac177en
dc.identifier.doihttps://doi.org/10.1093/cid/ciac177
dc.identifier.urihttp://hdl.handle.net/1974/30055
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relationMcMaster Medicine Specialty Resident and Fellows Research Granten
dc.subjectStaphylococcus aureusen
dc.subjectBacteremiaen
dc.subjectMortalityen
dc.subjectTrialsen
dc.titleHow Generalizable are Randomized Controlled trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studiesen
dc.typejournal articleen
project.funder.identifierhttp://dx.doi.org/10.13039/100009776en
project.funder.nameMcMaster Universityen

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