On certain two-signal perspectives of lymphocyte activation and inactivation, thymic G-quadruplexes, and the role of aggregation in self/not-self discrimination

Abstract

Distinctive “two signal” paths in immunology, taken by researchers with different academic backgrounds, seem to have both contained facets of the truth. Having been influenced by education at a medical school where Almroth Wright’s early contributions were not forgotten, the author’s “path less followed” led to views that began to gain recognition late in the twentieth century when the intimate relationship between innate and acquired immunity became more apparent.