Expedient Pd‐Catalyzed α‐Arylation towards Dibenzoxepinones. Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids
| dc.contributor.author | Deichert, Julie Amanda | |
| dc.contributor.author | Mizufune, Hideya | |
| dc.contributor.author | Patel, Jignesh J. | |
| dc.contributor.author | Hurst, Timothy E. | |
| dc.contributor.author | Maheta, Ashish | |
| dc.contributor.author | Kitching, Matthew | |
| dc.contributor.author | Ross, Avena | |
| dc.contributor.author | Snieckus, Victor | |
| dc.date.accessioned | 2020-05-15T14:55:47Z | |
| dc.date.available | 2020-05-15T14:55:47Z | |
| dc.date.issued | 2020-04-03 | |
| dc.description | This is the peer reviewed version of the following article: Deichert, J.A., Mizufune, H., Patel, J.J., Hurst, T.E., Maheta, A., Kitching, M.O., Ross, A.C. and Snieckus, V. (2020), Expedient Pd‐Catalyzed α‐Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids. Eur. J. Org. Chem.. doi:10.1002/ejoc.202000424, which has been published in final form at https://doi.org/10.1002/ejoc.202000424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | en |
| dc.description.abstract | The general synthesis of diversely substituted dibenzoxepinones by a combined Pd‐catalyzed α‐arylation and SNAr strategy is reported and applied to the synthesis of Manske's ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α‐arylation reaction. | en |
| dc.identifier.citation | Deichert, J.A., Mizufune, H., Patel, J.J., Hurst, T.E., Maheta, A., Kitching, M.O., Ross, A.C. and Snieckus, V. (2020), Expedient Pd‐Catalyzed α‐Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids. Eur. J. Org. Chem.. doi:10.1002/ejoc.202000424 | en |
| dc.identifier.doi | https://doi.org/10.1002/ejoc.202000424 | |
| dc.identifier.uri | http://hdl.handle.net/1974/27821 | |
| dc.language.iso | en | en |
| dc.publisher | Wiley | en |
| dc.subject | Alkaloids | en |
| dc.subject | Arylation | en |
| dc.subject | Homogeneous Catalysis | en |
| dc.subject | Nitrogen Heterocycles | en |
| dc.subject | Palladium | en |
| dc.subject | Synthetic Methods | en |
| dc.title | Expedient Pd‐Catalyzed α‐Arylation towards Dibenzoxepinones. Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids | en |
| dc.type | journal article | en |